QUANTITATIVE PROTEOMICS REVEALED THE PHARMACODYNAMIC NETWORK OF BUGU SHENGSUI DECOCTION PROMOTING OSTEOBLAST PROLIFERATION

Quantitative Proteomics Revealed the Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblast Proliferation

Background and ObjectiveWith high morbidity and disability, osteoporosis is a worldwide bone metabolism disease, regulated by complex pathological processes.Insufficient osteogenesis is greatly essential to osteoporosis.Traditional Chinese Medicine, a complex natural herbal medicine system, has increasingly attracted attention all over the world.Bu

read more

Cost-effectiveness model for a hypothetical monotherapy vs standard of care in adult patients with treatment-resistant depression

Si-Tien Wang,1 Ian M Anderson,2 Dominic Mitchell,3 Scott J Johnson,1 Aki Shiozawa4,5 1Medicus Economics, LLC, Boston, MA, USA; 2Neuroscience and Psychiatry Unit, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK; 3Medicus Economics, LLC, Repentigny, QC, Canada; 4Department of Health Policy and Management, Johns

read more

Numerical Simulation for Fractional-Order Bloch Equation Arising in Nuclear Magnetic Resonance by Using the Jacobi Polynomials

In the present paper, we numerically simulate fractional-order model of the Bloch equation by Spray Arm Retaining Cap using the Jacobi polynomials.It arises in chemistry, physics and nuclear magnetic resonance (NMR).It also arises in magnetic resonance imaging (MRI) and electron spin resonance (ESR).It is used for purity determination, provided tha

read more


Efficacy and safety profile of a subtilisin protease produced by fermentation in Bacillus licheniformis to be used as a feed additive

The efficacy and safety of a novel Subtilisin protease from a Bacillus sp.produced in Bacillus licheniformis was investigated in broiler chickens, and a range of toxicological tests, respectively.The B.licheniformis production strain culture supernatant was not found cytotoxic in a Vero cell assay.Subtilisin was non-mutagenic and non-clastogenic in

read more